Oh boy...
Just a few corrections here...
First, a 4.6L engine that is naturally aspirated can break a piston ring land from detonation. I know this, I have seen it! 1 psi of boost is enough to damage the internals on our engines. If you think it's the tune, you have a lot to learn. Yes a good tune helps, but the damn cylinder pressure is still there, isn't it? Yes. Intercoolers help, but they won't protect you either.
wannabesvt,
I have the stock 4.6L long block in my '95 T-Bird. So does EECDOC. We both runs 12's with our AED kits and make well over 300 RWHP.
You do not have to change the block.
Green bird,
You said "a set of PI heads will raise compression to 10.4:1 and running 6psi of boost, that gives an effective compression ratio of 14.64 This all means one thing...BOOM"
No, a blower NEVER changes the compression ratio of any engine. Period. It changes the air charge compression ratio. The C/R was 9.0:1 before the AED kit, it will be after. Without intercooling the air charge compression ratio would be 12.67:1 @ 6-psi. 8-psi gives you 13.89:1, again without intercooling.
I agree with you about PI heads on a non-PI block and a blower. That is a recipe for disaster since the cylinder pressures will skyrocket. Either the pistons will give up or the rods will. Or both. You really want 8.5:1-9.0:1 C/R with a blower. Anything higher is asking for a headache.
Blackjack_21,
You'll need forged internals to deal with a blower safely. Then you'll need a knock sensor, an ACT sensor and a very good tune on the dyno with a wide band 02. That will get you the power and longevity/durability you desire.
I run a stock '00 GT long block in my '95 T-Bird. It runs a fair amount of boost on the stock parts and while it won't last forever, it should hold up to a lot of abuse. Go lean though and you'll be in trouble.
A-Train